复方环丙沙星栓的制备及临床观察  

Preparation and clinical observation of compound ciprofloxacin suppository

作　　者：邢俊家[1] 刘阳[1] 

机构地区：[1]中国医科大学附属第一医院药剂科,辽宁沈阳110001

出　　处：《中国现代应用药学》2005年第z1期655-656,共2页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的研制抗滴虫性和细菌性阴道炎的栓剂,并对其临床疗效进行观察。方法以半合成脂肪酸甘油酯为基质,用常规方法制备复方栓剂。药物的含量用高效液相色谱法测定。结果制剂稳定性较好,对粘膜无刺激作用。临床应用表明,59例患者中57例完全治愈,2例好转,总有效率100%。结论复方环丙沙星栓安全、有效。OBJECTIVE The prescription and preparation of compound ciprofloxacin suppository in the treatment of trichomonas vaginitis and bacterial vaginitis were designed and studied.METHODS Semi-synthetic glyceryl stearate was used as base,the concents were determined by HPLC.RESULTS The preparation was stable and no stimulution to mucosa.Results of clinical tests showed,in 59 patients of trichomonas vaginitis and bacterial vaginitis,there were 57 ones had cured and 2 ones in well effects.CONCLUSION This formulation was safer and effective.

关 键 词：环丙沙星 替硝唑 栓剂 

分 类 号：R943.4[医药卫生—药剂学]