通心络对动脉硬化兔胸主动脉LOX-1表达干预的实验研究  

The effect of tong xin luo on the expression of Lox-1 in aorta of atherosclerotic rabbits

作　　者：刘忠志[1] 刘同宝[2] 李凤芝[1] 田静[1] 许晓群[3] 

机构地区：[1]山东聊城市人民医院,聊城252000 [2]山东省立医院 [3]山东省医学科学院

出　　处：《陕西医学杂志》2008年第8期951-953,974,共4页Shaanxi Medical Journal

摘　　要：目的:探讨通心络对动脉硬化兔胸主动脉植物血凝素样氧化低密度脂蛋白受体-1(LOX-1)表达的影响及机制。方法:将24只雄性新西兰大白兔随机分为正常饮食组、高脂饮食组及高脂饮食加通心络干预组,应用免疫组化测定兔胸主动脉中LOX-1的蛋白表达水平,用RT-PCR测定兔胸主动脉中LOX-1基因表达的水平。结果:高脂组及高脂饮食加通心络干预组胸主动脉中LOX-1蛋白及基因表达水平明显高于正常饮食组(P<0.05),通心络干预组胸主动脉中LOX-1蛋白及基因表达水平明显低于高脂饮食组(P<0.05)。结论:动脉硬化兔LOX-1蛋白及基因表达水平明显升高,通心络能够明显抑制动脉硬化兔LOX-1蛋白及基因表达。Objective:To explore the effect of Tong Xin Luo on the gene and protein expression of lox-1 in aorta of atherosclerotic rabbits and in mechnism.methods:Twenty-four male New Zealand white rabbits were randomly divided into three groups:normal diet group、hypercholesterol diet group、hypercholesterol diet plus Tong Xin Luo group,the protein expression of lox-1 in aorta of rabbits was examined by immunohistochemistry,the gene expression of lox-1 in aorta of rabbits was examined by RT-PCR.Results:The gene and pro...

关 键 词：动脉硬化/免疫学 受体 LDL @通心络 动物 实验 兔 

分 类 号：R285.5[医药卫生—中药学]