单硝酸异山梨酯脉冲控释微丸的制备及体外释药影响因素的研究  

Studies on Preparation of Isosorbide-5-mononitrate Pulsatile Controlled-release Pellets and Various Influence Factors

作　　者：王荣梅[1] 黄桂华[2] 方增军[1] 

机构地区：[1]山东大学第二医院,济南250033 [2]山东大学药学院,济南250012

出　　处：《生物医学工程学杂志》2008年第4期885-888,共4页Journal of Biomedical Engineering

摘　　要：制备单硝酸异山梨酯脉冲控释微丸并对影响释药的因素进行考察。采用挤出滚圆法制备载药丸芯,以水溶胀性材料为内包衣溶胀层,乙基纤维素水分散体为外包衣控释层制备脉冲控释微丸,并考察溶胀层材料类型、溶胀层和控释层包衣增重、介质pH值等对药物释放的影响。结果表明,该包衣微丸可脉冲释药,药物释放情况不受pH值的影响,低取代羟丙基纤维素与羟丙基甲基纤维素以一定比例混合作为内包衣层,乙基纤维素水分散体为外包衣层制备的脉冲控释微丸,当内包衣层增重为15%和外包衣层增重为13%时,达到了时滞为5h、时滞后1.5h累积释药80%以上的脉冲释药效果。We prepared the isosorbide-5-mononitrate pulsatile controlled-release pellets (PCRP) and studied the influencing factors in vitro.The isosorbide-5-mononitrate(5-ISMN)pellets prepared by extrusion-spheronization technology were coated with swelling material as the inner coating swelling layer, and with ethylcellulose aqueous dispersion as the outer coating controlled layer. The influences of the coating materials of the swelling layer, the coating levels of the swelling layer and controlled layer,and the pH ...

关 键 词：单硝酸异山梨酯 脉冲控释微丸 

分 类 号：R944.9[医药卫生—药剂学]