补肾解郁清心方对围绝经期抑郁症模型大鼠行为学及下丘脑-垂体-肾上腺轴的影响  

Effect of Bushen Jieyu Qinxin Decoction on the Behavior and Secretion of Hypothalamus-Pituitary-Adrenal Axis of the Perimenopausal Depression Model in Rat

作　　者：董莉[1] 姜琳[1] 孟炜[1] 朱南孙[1] 

机构地区：[1]上海中医药大学附属岳阳中西医结合医院,上海200437

出　　处：《中国实验方剂学杂志》2008年第5期63-65,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：上海市科委自然科学基金课题(04501)

摘　　要：目的:探讨补肾解郁清心方对围绝经期抑郁症模型大鼠行为学的影响和对下丘脑-垂体-肾上腺轴(HPA轴)的调节作用。方法:采用雌性SD大鼠双侧卵巢摘除,孤养与慢性轻度不可预见应激二步法制作围绝经期抑郁症动物模型。将40只大鼠分为正常对照组、模型组、西药组、中药组。西药组予百忧解(2.4 mg.kg-1)与苯甲酸雌二醇(0.1 mg.kg-1),中药组予补肾解郁清心方(40 g.kg-1,相当于临床成人剂量的10倍)。对大鼠进行Open-field行为学评分,糖水消耗实验,用酶联免疫吸附测定法(ELISA)检测血清促肾上腺皮质激素释放激素(CRH)、促肾上腺皮质激素(ACTH)、皮质酮(CORT)含量。结果:西药组和中药组Open-field水平积分、垂直积分及糖水消耗量均高于模型组(P<0.01);西药组和中药组血清CRH,CORT含量均低于模型组(P<0.05),ACTH含量有下降趋势。结论:补肾解郁清心方能够改善围绝经期抑郁症模型大鼠行为,调节HPA轴功能。Objective:To study the effect of Bushen Jieyu Qinxin Decoction(BJQD) on the behavior and secretion of the hypothalamus-pituitary-adrenal(HPA) axis of the perimenopausal depression model in rat.Methods:Perimenopausal depression modle was made by resecting the ovary of female SD rats combined with chronic unpredictable stress.40 rats were evenly randomized into control group,perimenopausal depression model group,Baiyoujie group and BJQD group,with 10 rats in each group.Open-field locomotors scores and sucrose...

关 键 词：补肾解郁清心方 围绝经期抑郁症 下丘脑-垂体-肾上腺轴 

分 类 号：R285.5[医药卫生—中药学]