清胰化积方对移植胰腺癌小鼠免疫抑制因子及脾淋巴细胞功能的影响  

Effect of Qingyi Huaji Formula on Serum Immunosuppressive Factors and Immune Function of Splenic Lymphocytes in Mice with Pancreatic Cancer

作　　者：张剑军[1] 陈震[1] 石卫东[1] 朱晓燕[1] 刘鲁明[1] 

机构地区：[1]复旦大学附属肿瘤医院

出　　处：《中国实验方剂学杂志》2008年第6期49-51,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：上海市科委资助重点项目(02DZ19106)

摘　　要：目的:观察清胰化积方对移植Panc02胰腺癌小鼠血清免疫抑制因子及脾淋巴细胞功能的影响。方法:将荷瘤小鼠随机分为5组:生理盐水组、白细胞介素-2(IL-2)组、清胰化积方小、中、大剂量组;观察给药后肿瘤变化,检测小鼠血清免疫抑制因子可溶性IL-2受体(sIL-2R)、转化生长因子β1(TGF-β1)、血管内皮生长因子(VEGF)的水平以及小鼠脾淋巴细胞增殖活性。结果:清胰化积方各剂量组胰腺癌移植瘤瘤重均小于NS组(P<0.05),血清sIL-2R、TGF-β1、VEGF水平均低于NS组,脾淋巴细胞增殖活性高于NS组(P<0.05)。结论:清胰化积方对胰腺癌体内生长有抑制作用,并能抑制免疫抑制因子的分泌、增强淋巴细胞功能,从而改善宿主的免疫抑制状态。Objective:To investigate the effect of Qingyi Huaji(QYHJ) Formula on serum immunosuppressive factors and proliferation activity of splenic lymphocytes of mice with pancreatic cancer Panc 02. Methods: The mice were randomly divided into NS group,interleukin-2(IL-2) group and QYHJ groups at low,medium and high dosages. After treatment, tumor growth was evaluated, the levels of serum immunosuppressive factors such as soluble interleukin-2 receptor(sIL-2R),transforming growth factor β_1(TGF-β_1) and vascular en...

关 键 词：清胰化积方 胰腺癌 免疫抑制因子 脾淋巴细胞 

分 类 号：R285.5[医药卫生—中药学]