加味鳖甲煎丸对肝纤维化大鼠血清IgG的影响  

The Effect of Jiaweibiejiajian Pill on Serum IgG of Rats with Hepatic Fibrosis

作　　者：孙海芸[1] 任映[1] 尹军祥[1] 宋崇顺[1] 叶永安[1] 杨金铎[1] 朱志慧[1] 戴欣[1] 

机构地区：[1]北京中医药大学东直门医院中药药理学实验室,北京100700

出　　处：《中国实验方剂学杂志》2008年第7期23-25,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：教育部科学技术研究重点项目(101361)

摘　　要：目的:观察加味鳖甲煎丸(JWBJ)对肝纤维化大鼠模型血清IgG的影响。方法:用人血清白蛋白和CCl4的方法[1]分别制作大鼠肝纤维化模型,在成模前预防治疗和成模后治疗,用免疫扩散法测定大鼠血清IgG含量。结果:JWBJ预防治疗大,中剂量组及治疗大剂量组与各自的模型组相比均可使白蛋白所致肝纤维化大鼠血清IgG含量明显降低(P<0.05);JWBJ预防治疗大剂量组与模型组相比可使CCl4所致肝纤维化大鼠血清IgG含量明显降低(P<0.05)。结论:JWBJ可降低人血清白蛋白和CCl4所致肝纤维化大鼠过度产生的IgG,表明JWBJ对机体免疫功能有一定的调节作用,对肝纤维化的治疗有一定的参考意义。Objective:To investigate the effects of Jiaweibiejia(JWBJ) Pills on the IgG in serum of hepatic fibrosis rats(HFR).Methods:The rats were randomly divided into control group,model groups,colchine group and Ganpikang group.The model groups were treated or pre-treated with low-dose,middle-dose or high-dose of JWBJ.The serum IgG taken from each group was tested with immunodiffusion method.Results:In the HFR induced by HSA,the level of serum IgG was significantly decreased when treated with the high-dose JWBJ or...

关 键 词：加味鳖甲煎丸 肝纤维化 免疫球蛋白 

分 类 号：R285.5[医药卫生—中药学]