疏肝健脾法调控肠易激综合征动物模型胃肠激素水平的研究  

Study on the Method of Soothing the Liver and Strengthening the Spleen on Regulating Gastrointestinal Hormones in Animals Model of Irritable Bowel Syndrome

作　　者：李冬华[1] 朱飞鹏[2] 李珊珊[1] 王帅[1] 马丛[1] 黄亚娜[1] 

机构地区：[1]首都医科大学中医药学院,北京100069 [2]国家药品审评中心,北京100038

出　　处：《中国实验方剂学杂志》2008年第7期20-23,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：首都医科大学自然科学科研基金(2004ZR06);国家中医药管理局中医药科学技术研究专项课题(06-07ZQ01)

摘　　要：目的:观察疏肝健脾法对肠易激综合征动物模型胃肠激素水平的影响。方法:将32只Wistar大鼠随机分为正常对照组、模型组、痛泻要方组、得舒特组。采用束缚应激刺激加灌服番泻叶煎剂的方法造成肠易激综合征(IBS)大鼠模型,观察各组大鼠稀便率,以放射免疫法检测各组大鼠血浆及局部肠组织中生长抑素(SS)、P物质(SP)水平的变化。结果:痛泻要方组经治疗后,稀便率下降,与模型组比较有统计学意义(P<0.05);模型组大鼠血浆和局部肠组织中SS、SP水平较正常对照组明显升高(P<0.05,P<0.01);痛泻要方组血浆及局部肠组织中SS、SP水平较模型对照组明显降低(P<0.05)。结论:疏肝健脾法对IBS动物模型胃肠激素有调控作用,能降低IBS动物模型体内SS、SP的分泌释放水平。Objective:To observe the effects of the method of soothing the liver and strengthening the spleen on gastrointestinal hormone somatostain(SS) and substance P(SP) in animals model of irritable bowel syndrome(IBS).Methods:32 Wistar rats were divided randomly into normal control group,model group,Tongxieyaofang group and dicetel group.The rat model of irritable bowel syndrome(IBS) was made by binding stress with taking senna decoction.Changes of diarrhea rate were observed in these groups.Radioimmunoassay was ...

关 键 词：生长抑素 P物质 肠易激综合征 疏肝健脾法 

分 类 号：R259[医药卫生—中西医结合]