黏膜给药原位凝胶的研究进展  

Advances in the Studies on In Situ Gels by Mucosal Drug Delivery

作　　者：陈两绵[1] 王锦玉[1] 仝燕[1] 彭新君[2] 

机构地区：[1]中国中医科学院中药研究所,北京100700 [2]湖南中医药大学药学院,湖南长沙410208

出　　处：《中国实验方剂学杂志》2008年第8期76-80,共5页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：介绍了黏膜给药原位凝胶的优点、分类、常用聚合物,以及原位凝胶在各黏膜给药部位的应用情况。作为一种新型的药物传递系统,黏膜给药原位凝胶虽还存在一些技术难点有待攻克,但它结合了原位凝胶制剂和黏膜给药途径双重优势,是一个很有发展潜力的药物传递系统,尤其在中药新剂型的研究方面有着广阔的发展前景。The progress in the studies of temperature-sensitive,pH-dependent,ion-responsive in situ gels by mucosal drug delivery was reviwed and the applications of in situ gels in all mucosal parts were introduced.Although there were some technical problems remained in situ gel by combining the dosage form of in site gel with the route of mucosal administration,it was a novel drug delivery system with high developing potentials,especially in the study of dosage forms of traditional Chinese medicine.

关 键 词：原位凝胶 黏膜给药 药物传递系统 

分 类 号：R94[医药卫生—药剂学]