桂枝芍药知母汤对免疫性关节炎治疗作用的实验研究  

The Experimental Study on Therapeutic Mechanism of GSZ Decoction on Immunologic Arthritis

作　　者：余方流[1] 董群[1] 

机构地区：[1]安徽皖南医学院微生物与免疫学教研室,安徽芜湖241001

出　　处：《中国实验方剂学杂志》2008年第8期41-44,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:观察桂枝芍药知母汤对免疫性关节炎的治疗作用,并初步探讨其作用机制。方法:以弗氏完全佐剂诱导产生免疫性关节炎模型,用不同剂量桂枝芍药知母汤(GSZ汤20.6、10.3g.kg-1)给模型动物灌胃用药,观察用药后动物致炎对侧膝关节滑膜组织病理改变与RANKL表达。结果:桂枝芍药知母汤用药4周后,可明显减轻关节肿胀程度,使关节指数减小(P<0.05orP<0.01);病理镜检显示,大鼠膝关节滑膜细胞和纤维组织增生减轻,浸润细胞数减少;滑膜组织RANKL表达下降(P<0.01),本实验条件下,GSZ汤20.6g.kg-1剂量时的疗效与MTX相当。结论:桂枝芍药知母汤对免疫性关节炎大鼠的关节损伤有治疗和保护作用,其机制可能与抑制炎症反应并降低RANKL表达有关。Objective:To observe the therapeutic effect of Guizhi-Shaoyao-Zhimu(GSZ) decoction on imunologic arthritis and investigate the mechanism of this drug on the disease.Methods:Rats were prepared for immunologic arthritis models induced by Freund s complete adjuvant(FCA).Different doses of GSZ decoction(20.6 g·kg-1,10.3 g·kg-1) were administrated on the rat model.The counter-lateral synovial tissues of the knee joint were taken for observing pathological changes and the expression of RANKL.Results:In a 4-week o...

关 键 词：桂枝芍药知母汤 免疫性关节炎 NF-κB受体活化因子配体 

分 类 号：R285.5[医药卫生—中药学]