米力农在Switch术中的应用  

The Use of Milrinone in Arterial Switch Operations

作　　者：胡彦艳[1] 宋兴荣[2] 王晟[2] 

机构地区：[1]广西壮族自治区人民医院麻醉科,广西南宁530021 [2]广东省人民医院心血管病研究所麻醉科,广东广州510080

出　　处：《中外医疗》2008年第20期170-172,共3页China & Foreign Medical Treatment

摘　　要：目的评价米力农(milrinone)在大动脉调转术(Switch术)中对血流动力学的影响及应用效果。方法40例行Switch术患儿,随机分为两组:M组,主动脉开放后,米力农50μg/kg负荷量10min静注后以0.5μg.kg-1.min-1维持;N组,与M组等量的生理盐水10min静注后硝酸甘油以0.5～2.0μg.kg-1.min-1维持。观察CPB前、给药后5、15、30、60min、缝皮时的HR、MAP、CI、PCWP、SVR、PVR、LVSWI和RVSWI的变化。结果与N组比较,M组给药后CI、LVSWI、RVSWI明显增加(P<0.05),PCWP、SVR、PVR明显降低(P<0.05),HR、MAP变化无统计学意义(P>0.05)。结论米力农增加心肌收缩力,降低心脏前后负荷,有助于维持Switch术的血流动力学稳定。Objective To evaluate the hemodynamic effects of milrinone on arterial switch operations.Methods 40 neonats or infants undergoing Switch were randomly divided into two group:M group, milrinone was administered at a 50ug/kg bolus intravenously at ten minutes,followed by a continueous infusion of 0.5μg.kg-1.min-1 at post release of the cross clamp.N group, the same volume of normal saline bolus dose intravenously,Nitroglycerin was followed by a continueous infusion of 0.5～2.0μg.kg-1.min-1 at post release of t...

关 键 词：米力农 SWITCH术 血流动力学 

分 类 号：R726.5[医药卫生—儿科]