禽流感H5N1病毒不同途径感染BALB/c小鼠的临床和病理比较  

The Comparison of Clinical Signs and Pathologic Changes of Avian Influenza Virus (H5N1) to BALB/c Mice

作　　者：闵凡贵[1] 刘香梅[1] 赵维波[1] 王静[1] 张钰[1] 刘忠华[1] 黄韧[1] 

机构地区：[1]广东省实验动物监测所,广州510260

出　　处：《中国实验动物学报》2005年第S1期57-,共1页Acta Laboratorium Animalis Scientia Sinica

摘　　要：我们将禽流感H5N1病毒通过鼻腔、尾静脉和脑内接种方式接种BALB/c小鼠,观察小鼠在感染过程中临床症状和各个组织器官的病理变化。感染1天后,小鼠打堆、猥琐、毛色混乱、眼角有分泌物;感染第2天的小鼠均出现死亡;感染4天后,小鼠从临床症状上表现恢复。收集各种方式感染的小鼠的主要脏器进行组织病理学检查,结果显示,小鼠不同接种途径感染H5N1流感病毒后,所产生的病理变化相似;从各个脏器的病变程度来看,病毒最先到达的器官损伤最严重。感染第2天各组织器官的病变最严重,随着感染时间增长,肺脏和肾脏等器官有不同程度的恢复,心脏和肝脏等器官的病变在感染过程中未见明显恢复。To understand the mechanisms of H5N1 pathogenicity, we infected 6 to 8-week-old BALB/c mice by different routes of viral inoculation. The virus caused severe disease in mice, characterized by induced hypothermia, rapid weight loss, and high mortality by 2 days postinfection. And the main clinical signs of the animals began to recover by 4 days postinfection. The most severe and widespread lesions were observed in the organs of virus-infected mice, where received the virus firstly. Only mild lesions or no le...

关 键 词：禽流感H5N1病毒 鼻腔接种 静脉接种 脑内接种 病理变化 

分 类 号：S855.3[农业科学—临床兽医学]