甘草酸单铵配伍复方丹参注射液预防大鼠子宫角粘连及对粘连局部tPA、PAI活性影响的研究  

Effect of Monoammonium Glycyrrhetate Combined with Compound Salvia Miltiorrhizae Injection in Preventing Uterine Horn Adhesion of Rats and the Activity of Tissue Plasminogen Activator and Plasminogen Activator Inhibitor

作　　者：王莉[1] 于俊荣[2] 樊瑞琴[2] 刘效群[2] 齐惠敏[2] 

机构地区：[1]石家庄市第四医院,石家庄050011 [2]河北省计划生育科学技术研究所

出　　处：《中国中西医结合杂志》2005年第S1期145-148,共4页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的观察甘草酸单铵盐(mono ammonium glycyrrhetate,MAG)配伍复方丹参注射液对大鼠子宫角粘连的预防作用及其对大鼠腹腔液和子宫角粘连局部组织中tPA-a、PAI-a的影响。方法将大鼠分6组,制作大鼠子宫角粘连模型。MAG组给予MAG 5m/kg,复方丹参组给予复方丹参注射液1ml/kg,MAG加复方丹参组给予MAG 5mg/kg及复方丹参注射液1ml/kg,地塞米松磷酸钠(Dex)组给予Dex 1mg/kg,模型组给予生理盐水10ml/kg,空白对照组未实行任何处理。参照Leach的方法观察粘连评分、取腹腔液和局部粘连组织测组织纤溶酶原激活剂活性(tPA-a)和纤溶酶原激活抑制剂活性(PAI-a)。结果与模型组比较,MAG、MAG加复方丹参、Dex组明显降低粘连评分及严重粘连百分率(P＜0．01),单用复方丹参未降低粘连评分。与模型组比较,复方丹参组与MAG加复方丹参组明显升高腹腔液tPA-a和tPA/PAI。与空白组比较,模型组明显升高了宫角组织中PAI-a、明显降低组织tPA/PAI,其它各实验组均明显升高组织tPA-a和tPA/PAI(P＜0．01),且MAG加复方丹参组、Dex组明显降低组织PAI-a。结论本研究进一步证明了术后粘连形成过程包括局部纤溶活性降低过程的理论；证明了MAG和MAG伍用复方丹参具有预防粘连和提高纤溶活性的作用,且联合应用优于MAG单用。Objective To evaluate the effects of monoammonium glycyrrhetate(MAG)combined with com- pound Salvia Mihiorrhizae injection(CSM)on the prevention of uterine horn adhesion and the activity of tissue plasminogen activator(tPA-a)and plasminogen activator inhibitor(PAI-a)in hydrops abdominis and tissues of u- terine horn.Methods Rat models of uterine horn adhesion were established.The rats were divided into 6 groups, 10 in each.In the MAG group,the rats were given 5mg/kg MAG intraperitoneally;in the CSM group,1m...

关 键 词：甘草单铵盐 复方丹参 预防粘连 子宫角 

分 类 号：R285[医药卫生—中药学]