糖肾胶囊对FFR模型骨骼肌及脂肪组织GLUT4mRNA表达的影响  

Effect of Tangshen Capsules on mRNA Expression of GLUT4 in Skeletal Muscle and Adipose Tissue of Fructose-fed Rats

作　　者：李怡[1] 欧阳涛[2] 吴翥镗[1] 刘素梅[3] 刘震[1] 李晔[1] 齐若梅[2] 

机构地区：[1]卫生部北京医院,北京100730 [2]卫生部老年医学研究所 [3]中国医学科学院实验动物研究所

出　　处：《中国中西医结合杂志》2005年第S1期133-136,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金(No.39900200)

摘　　要：目的探讨糖肾胶囊对高果糖餐大鼠(fructose-fed rats,FFR)模型胰岛素抵抗(insolin resistance IR)改善的机制。方法20只清洁级6周龄雄性SD大鼠随机等分为4组,即正常对照组以标准餐喂养,后三组(模型对照组、糖肾胶囊组、文迪雅组)以高果糖餐喂养4周即可成模。成模后三组分别投喂生理盐水和糖肾胶囊(800mg·kg^(-1)·d^(-1))、文迪雅(2 mg·kg(-1)·d(-1))4周。取各组大鼠的骨骼肌和脂肪组织,分别用RT-PCR和荧光定量PCR技术对两种组织的GLUT4mRNA进行定性定量分析。结果糖肾胶囊能减少骨骼肌和增加脂肪组织的GLUT4mRNA表达(P＜0．05)。结论糖肾胶囊可能是通过影响骨骼肌和脂肪组织GLUT4mRNA表达改善胰鸟素抵抗的。Objective To explore the machanism of Tangshen capsules(TSC)in improving insulin resist- ance(IR)of fructose-fed rats(FFR).Methods Twenty six-week-old male Sprague-Dawley rats of clean grade were randomly divided into four groups(n=5),i.e.,the normal control group,the model group,TSC group and Avadia group.Rats in the normal group were fed with normal diet(60% vegetable strach,11% fat and 29% pro- tein),while those in the latter three groups were fed with fructose-rich diet(66% fructose,12% fat and 22% pro-...

关 键 词：糖肾胶囊 高果糖餐大鼠 骨骼肌 脂肪组织 葡萄糖载体4 

分 类 号：R285[医药卫生—中药学]