川芎挥发油对小鼠神经功能的影响  

Effect of Ligusticum Chuanxiong Hort Essential Oil on Nerve Function of Mice

作　　者：阮琴[1] 姜科声[1] 何新霞[1] 胡燕月[1] 

机构地区：[1]浙江师范大学化学与生命科学学院,浙江金华321004

出　　处：《中国中西医结合杂志》2005年第S1期23-25,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：浙江省教育厅项目(N0.20010073)

摘　　要：目的研究川芎挥发油对小鼠自主活动及对阈下剂量戊巴比妥钠催眠作用的影响。方法腹腔注射川芎挥发油6、3及1μl,观察用药前后小鼠自主活动、旷场行为的改变、对阈下剂量戊巴比妥钠催眠作用的影响。结果6μl川芎挥发油能引起小鼠自主活动减少(P＜0．05),使阈下剂量戊巴比妥钠致小鼠睡眠时间延长(P＜0．01),能加强阈下剂量戊巴比妥钠的催眠作用。而3及1μl川芎挥发油对小鼠自主活动和戊巴比妥钠阈下剂量作用催眠均无明显影响(P＞0．05)。结论高剂量的川芎挥发油具有中枢抑制作用,表现为镇静催眠。Objective To study the effect of Ligusticum Chuanxiong Hort Essential Oil(LEO)on the sponta- neous activity,and on the hypnotic action with pentobarbital in subthreshold dose.Methods The changes of spontaneous activity and open-field activity before and after treatment,and its hypnotic action of subthreshold pen- tobarbital dosage by peritoneal injection of LEO of 6,3 and 1μ1.Results LEO of 6μl could induce the reduc- tion of spontaneous activity of mice(P＜0.05),prolong pentobarbital hypnotic time(P＜0.01),s...

关 键 词：川芎挥发油 自主活动 旷场行为 阈下催眠 

分 类 号：R285[医药卫生—中药学]