硝酸酯类对支架术后冬眠心肌的影响  

Effect of nitrate on contractile function of hibernating myocardium after PTCA plus stenting

作　　者：姚力[1] 吕欣[1] 李金明[1] 侯子山[1] 

机构地区：[1]山东省临沂市人民医院心内科,山东临沂276003

出　　处：《安徽医药》2004年第5期335-336,共2页Anhui Medical and Pharmaceutical Journal

摘　　要：目的　观察经皮冠状动脉腔内成形术 (PTCA) +支架植入术后 ,继续使用硝酸酯类药物对冬眠心肌功能的影响。方法　对 6 0例PTCA +支架植入术后的冠心病患者继续服用硝酸酯类药物 6个月后 ,采用小剂量多巴酚丁胺负荷超声心动试验 ,计算室壁节段运动指数 (WMSI)来判断冬眠心肌的恢复情况。结果　PTCA +支架植入术可改善冬眠心肌的功能 ,术后继续服用硝酸酯类药物可进一步促进冬眠心肌功能的恢复 ,两者相比差异有显著性 (P <0 0 1 )。结论　PTCA +支架植入术后继续服用硝酸酯类药物较单纯PTCA +支架植入术治疗 。Aim To investigate the effect of nitrate on contractile function of hibernating myocardium after PTCA plus stenting. Methods Sixty patients with coronary heart disease were treated with isosorbidi mononitras 40 mg daily for 6 months after PTCA plus stenting and underwent low dose dobutamine echocardiography before and after PTCA plus stenting . Left ventricular regional wall motion in each segment was graded and scored using a 16 segment model and the semiquantitative analysis method to demonstrate the recovery of hibernating myocardium. Results The contractile function of hibernating myocardium was improved after PTCA plus stenting which was better in patients with isosorbidi mononitras (P <0 01). Conclusion The recovery of contractile function of hibernating myocardium in nitrate group is better than that in PTCA plus stenting group

关 键 词：经皮冠状动脉腔内成形术(PTCA) 支架植入术 硝酸酯类 冬眠心肌 

分 类 号：R541.4[医药卫生—心血管疾病] R969[医药卫生—内科学]