LOW MOLECULAR WEIGHT O-CARBOXYMETHYLATED CHITOSANS DERIVED FROM IRRADIATED CHITOSAN AND THEIR ANTIBACTERIAL ACTIVITY  

作　　者：管云林 

机构地区：[1]School of Materials Science and Engineering,Tianjin University, Tianjin 300072, China

出　　处：《Chinese Journal of Polymer Science》2004年第6期521-527,共7页高分子科学（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China (No. 50173019).

摘　　要：Original chitosan with M-v of 2.7 x 10(5) was degraded by irradiation with gamma-rays and a series of low molecular weight O-carboxymethylated chitosans (O-CMCh) were prepared based on the irradiated chitosan. A kinetic model of the irradiation of chitosan was put forward. Results show that the irradiation degradation of chitosan obeys the rule of random degradation and the degree of deacetylation of irradiated chitosan is slightly raised. The antibacterial activity of O-CMCh is significantly influenced by its MW, and a suppositional antibacterial peak appears when M-v is equal to 2 x 10(5).Original chitosan with M-v of 2.7 x 10(5) was degraded by irradiation with gamma-rays and a series of low molecular weight O-carboxymethylated chitosans (O-CMCh) were prepared based on the irradiated chitosan. A kinetic model of the irradiation of chitosan was put forward. Results show that the irradiation degradation of chitosan obeys the rule of random degradation and the degree of deacetylation of irradiated chitosan is slightly raised. The antibacterial activity of O-CMCh is significantly influenced by its MW, and a suppositional antibacterial peak appears when M-v is equal to 2 x 10(5).

关 键 词：CHITOSAN O-carboxymethylated chitosan irradiation degradation antibacterial activity molecular weight 

分 类 号：O636.1[理学—高分子化学]