黏膜免疫佐剂的研究进展  

Advances in the research of mucosal immune adjuvant

作　　者：张小飞[1] 杨倩[1] 

机构地区：[1]南京农业大学农业部动物生理生化重点开放实验室,江苏南京210095

出　　处：《免疫学杂志》2004年第z1期62-65,共4页Immunological Journal

基　　金：国家自然科学基金(30070564);江苏省自然科学基金(BK2002111)资助项目

摘　　要：黏膜免疫系统是机体抵抗外来病原体入侵的第一道防线,弱毒苗通过黏膜免疫后可引起局部和全身性的免疫应答。由于疫苗经过消化道时常受到消化液的降解,在应用中不得不增加抗原的用量。因此为了提高机体对抗原的黏膜免疫力和系统免疫反应,不同类型黏膜免疫佐剂已悄然进入黏膜免疫的研究中。本文就近几年来国内外黏膜免疫佐剂的研究情况作一综述。Mucosal immune system is the first line of defense against foreign invaders. Mucosal and systemic immune response can be induced by attenuated vaccine. However, the digestive juice through the alimentary tract often degrades the vaccine, so the amount of the antigen has to be increased in clinical practice. In order to improve organism mucosal immunity and system immune response against the antigen, different kinds of mucosal immune adjuvant have been studied. The article gives a detail summarization on the recent studies about mucosal immune adjuvant.

关 键 词：黏膜免疫 佐剂 疫苗 

分 类 号：R392[医药卫生—免疫学]