Facile Synthesis of 3,3-Di(1H-indol-3-yl)indolin-2-ones Catalyzed by Ceric Ammonium Nitrate (CAN) under Ultrasound Irradiation  

作　　者：WANG,Shun-Yi ZENG,Xiao-Fei ZHOU,Wei-Juan JI,Shun-Jun 

机构地区：[1]Key Laboratoy of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Suzhou University, Suzhou 215006

出　　处：《有机化学》2004年第z1期262-263,共2页Chinese Journal of Organic Chemistry

基　　金：Project supported by the National Natural Science Foundation of China (No. 20172039).

摘　　要：Indole fragment is featured widely in a wide variety of pharmacologically and biologically active compounds.[1] The 3,3-bis(3-indolyl)oxindole has been shown to possess antibiotic activities against Escherichia coli, Bacillus subtilis and Staphylococcus aureus. [2] As a continue of our work on the synthesis of indole derivates such as bis(indolyl)methanes,[3]we describe an ultrasound-accelerated reaction of isatin 1 with indoles 2 using a catalytic amount of ceric ammonium nitrate (CAN), which provides an efficient route to the synthesis of 3,3-di(1H-indol-3-yl)indolin-2-ones.……

分 类 号：O62[理学—有机化学]