Development of a Novel, Oxidatively Activated, Safety-Catch Linker for Solid-Phase Asymmetric Organic Synthesis (SPOS)  

作　　者：LIN,Jun Hjalmar Skarphedinsson Stepehen G.Davies 

机构地区：[1]Department of Applied Chemistry, Yunnan University, Kunming 650091 The Dyson Perrins Laboratory, University of Oxford, South Parks Road, Oxford, OX1 3QY, UK The Dyson Perrins Laboratory, University of Oxford, South Parks Road, Oxford, OX1 3QY, UK

出　　处：《有机化学》2004年第z1期334-335,共2页Chinese Journal of Organic Chemistry

基　　金：云南省技术创新人才基金(No.2001PY011)及云南大学校基金(No.2003Q001A)资助项目.

摘　　要：　　Solid-phase asymmetric organic synthesis has become a very important synthetic strategy within the organic chemistry community.[1] Critical to success in SPOS is a linking strategy which allows both the substrate to be loaded and the product released efficiently from the polymeric support. A safety catch linker[2] (SCL) is in principle a linking molecule orthogonal to the reaction conditions of the library synthesis, which can be easily activated by a simple chemical transformation to allow efficient cleavage of the products from the polymer under mild conditions. In order to introduce the SuperQuat chiral auxiliaries[3] for SOPS, we report herein design and synthesis of a novel safety catch linker for asymmetric conjugate addition reactions.……

分 类 号：O62[理学—有机化学]