A Facile Three-Component One-Pot Synthesis of Structurally Constrained Tetrahydrofurans, Which Are t-RNA Synthetase Inhibitor Analogues  

作　　者：LU,Chong-Dao CHEN,Zhi-Yong HU,Wen-Hao MI,Ai-Qiao 

机构地区：[1]Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041

出　　处：《有机化学》2004年第z1期40-40,共1页Chinese Journal of Organic Chemistry

基　　金：Project supported by the Chinese Academy of Sciences and the National Natural Science Foundation of China (No. 20202011).

摘　　要：A one-pot procedure for the efficient synthesis of a small library of t-RNA inhibitor analogues was developed. Thus,Rh2(OAc)4 catalyzed three-component 1,3-dipolar cycloaddition reactions of carbonyl ylides derived from diazoindan-1,3-dione and aldehydes with other dipolarophiles in 1,1,2,2-tetrachloroethane at 80 ℃ gave ring fused tetrahydrofurans having three stereocenters in good yield.……

分 类 号：O62[理学—有机化学]