Small Peptides Catalyzed Direct Aldol Reactions of Aldehydes with Hydroxyacetone with Regiocontrol in Aqueous Media  

作　　者：TANG,Zhuo YANG,Zhi-Hua CUN,Lin-Feng GONG,Liu-Zhu MI,Ai-Qiao JIANG,Yao-Zhong 

机构地区：[1]Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041

出　　处：《有机化学》2004年第z1期41-42,共2页Chinese Journal of Organic Chemistry

摘　　要：Very recently, we[1] found that L-proline amides and dipeptides acted as efficient catalysts for the asymmetric direct aldol reaction. We report here that L-proline-based peptides 1~5 can catalyze the aldol reactions of hydroxyacetone with aldehydes 6 in aqueous media, to give 1,4-diols (7), the disfavored products with either aldolase or L-proline. Both peptides 3 and 4 give good results.……

分 类 号：O62[理学—有机化学]