Synthesis of Novel Thiol Taxoid Based on the 7,10-Di-(2,2,2-trichloroethyl-oxycarbonyl)-10-deacetylbaccatin Ⅲ and (4R,5S)-2,4-Diphenyl-2-oxazoline-5-carboxylic acid: (2'R,3'R)-10-Deacetyl- 2'-deoxy-mercaptopaclitaxel  

作　　者：XU,Li QI,Xin ZHOU,Zhi-Ping 

机构地区：[1]Information College of Science and Technology, Nanjing Forestry University, Nanjing 210037 School of Chemical Engineering, Dalian University of Technology, Dalian 116012 College of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093

出　　处：《有机化学》2004年第z1期57-58,共2页Chinese Journal of Organic Chemistry

摘　　要：　　The complex natural product paclitaxel (TaxolR) 1, first isolated from Taxus brevifolia, and its semisynthetic analog,docetaxel 2, represent a large family of taxane diterpenoids, which revealed excellent clinical activity against ovarian and breast cancers, and showed promising results in the treatment of other cancers.[1] Extensive studies on the structure activity relationship (SAR) have been explored. It is already well known that a free hydroxyl group at the C-2' position on the C-13 side chain is crucial for microtubule binding[2] and may act as a hydrogen bond donor.……

分 类 号：O62[理学—有机化学]