小剂量^(131)碘治疗毒性弥漫性甲状腺肿327例疗效分析  

The Therapeutic Effect on 327 cases of Graves' Diseases with Small Dosage of ^(131)I

作　　者：唐晓燕[1] 刘子太[1] 王羽[1] 郑合明[1] 李小烽[1] 罗君[1] 柯庚寅[1] 王传刚[1] 杜正旺[1] 

机构地区：[1]河南省卫生防疫站,中国河南郑州450003

出　　处：《实用预防医学》2004年第4期680-681,共2页Practical Preventive Medicine

摘　　要：目的　探讨小剂量　13 1碘分次疗法治疗毒性弥漫性甲状腺肿的疗效。　方法　13 1I剂量降至常规计算用量的 1/2～ 2 /3 ,1次顿服 ,3个月为 1个疗程 ,进行疗效复查 ,总剂量 1.5～ 8　mCi。　结果　 3 2 7例患者中 ,痊愈 3 0 9例 ,治愈率 94.5 % ,未愈 14例 ,占 4.3 % ,4例出现早发甲状腺功能低下 (甲低 ) ,经治疗或观察半年后恢复。治愈总疗程 1～ 3个 ,时间 3～ 9个月。痊愈病例中 ,服药 1个疗程治愈 98人 ( 3 1.7% ) ,2个疗程治愈 182人 ( 5 8.9% ) ,3个疗程治愈 2 9人( 9.4% ) ,观察 5～ 11年 ,3 0 9例治愈患者中未出现甲亢复发或晚发甲低。　结论　小剂量　13 1I是治疗毒性弥漫性甲状腺肿安全、有效的方法。Objective To investigate the clinical treatment of Graves' diseases with small dosage of 131 I. Methods We reduced the dosage of 131 I to 1/2～2/3 of the calculated quantity,counterchecked the patients who took 131 I one time per three months,three months was one therapeutic course,the total dosage was 1.5～8.0 mCi. Results 309 cases were cured in 327 cases,the cure rate was 94.5%. 14 cases were not cured. Early hypothyroidism occurred in 4 cases and recovered after treatment. The total time was 3～9 months,1～3 therapeutic course. Of all cured cases,98 cases were cured in the first course(31.7%),182 in the second course(58.9%),29 in the third course(9.4%). 309 of all cured cases didn't have relapsed hyperthyroidism or late hypothyroidism. Conclusions The method to treat Graves' diseases with small dosage of 131 I is safe and effective.

关 键 词：小剂量 131碘 毒性弥漫性甲状腺肿 治疗 

分 类 号：R581.3[医药卫生—内分泌]