鼻敏片对豚鼠鼻超敏反应影响的研究  

Study of Bimin Tablet on the Nasal Hypersensitivity of Guinea Pigs

作　　者：周光源[1] 李凡成[1] 徐绍勤[1] 文志[1] 

机构地区：[1]湖南中医学院第二附属医院耳鼻咽喉科,长沙410005

出　　处：《中国中西医结合杂志》2004年第S1期219-221,共3页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的研究中成药鼻敏片对豚鼠变应性鼻炎动物模型的影响。方法将60只豚鼠随机分为6组,即正常、模型、对照、治疗(鼻敏片分高、中、低剂量各1组),每组各10只,以二异氰酸甲苯酯(TDI)为致敏源,对豚鼠行鼻内给药法建立鼻超敏反应动物模型,以息斯敏为对照,以豚鼠鼻分泌物涂片的细胞学检查、鼻甲粘膜组胺含量及血浆 P 物质为指标,探讨鼻敏片的作用和机理。结果模型组鼻分泌物中嗜酸性细胞、肥大细胞组胺及血浆 P 物质含量高于正常组,鼻敏片中、高剂量组均能有效降低上述指标,息斯敏组对相关指标影响不明显,鼻敏片低剂量组对血浆 P 物质含量影响不明显。结论鼻敏片通过阻断变应性鼻炎发病的多个环节而显效,对治疗变应性鼻炎具有一定的作用。Objective To study the effect of Bimin tablet(BMT),a TCM patent medicine,on the animal model of Guinea pigs with allergic rhinitis.Methods Sixty Guinea pigs were randomly divided into six groups,i.e.normal,model,control, high-dose,middle-dose and low-dose of BMT treated group,10 in each.Nasal hypersensitivity model was set up by instill- ing toluene 2,4 diisocyanate(TDI)as the sensitizer.Astemizole tablet was used as the control.Cytological examination of the nasal secretion,histamine content of nasal conch...

关 键 词：变应性鼻炎 鼻敏片 血浆 P 物质 嗜酸性细胞 肥大细胞 组胺 

分 类 号：R285.5[医药卫生—中药学]