参附注射液对失血性休克兔腹腔脏器再灌注损伤的保护效应  

Protective Effect of Shenfu Injection on lschemia/Reperfusion Injury of Celiac Viscera in Hemorhagic Shock Rabbits

作　　者：吴灵潝[1] 邹捍东[1] 余金甫[1] 王龙[1] 熊桂先[1] 

机构地区：[1]武汉大学人民医院麻醉科,武汉430060

出　　处：《中国中西医结合杂志》2004年第S1期20-23,共4页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的观察参附注射液对控制性失血性休克兔肝、小肠、胰腺再灌注损伤的保护效应。方法 18只健康家兔随机分为假手术组,对照组和治疗组,(每组6只)。采用 Lamson 休克模型,维持平均动脉压(MAP)在40mmHg 90min,再灌注90min 后检测肝、小肠、胰腺组织中丙二醛(MDA)、超氧化物歧化酶(SOD)、肿瘤坏死因子(TNFα)及细胞间黏附分子1(ICAM-1)水平。观察对照组和治疗组的小肠末段组织超微结构。结果再灌注90min 后治疗组兔肝、小肠、胰腺 MDA、TNFα及 ICAM-I 水平显著低于对照组(P<0.05或P<0.01);SOD 水平显著高于对照组(P<0.05)。结论参附注射液可在一定程度上减少兔失血性休克后腹腔脏器再灌注损伤的脂质过氧化反应和炎性反应。Objective To observe the protective effect of Shenfu Injection (SFI) on ischemia/reperfusion (I/R) injury of liver,small intestine and pancreas in rabbits with controlled hemorrhagic shock.Methods Eighteen healthy rabbits were randomly divided into the sham operation group,the control group and the treated group,six in each.Using Lam- son shock model,after mean arterial pressure (MAP) being maintained at 40 mmHg for 90 rain,followed with 90 min of reperfusion,levels of malondialdehyde (MDA),superoxide dismu...

关 键 词：失血性休克 再灌注损伤 参附注射液 腹腔脏器 

分 类 号：R285.5[医药卫生—中药学]