络活胶囊治疗高血压病的实验研究  

Experimental Study of Luohuo Capsule in Treating Hypertension

作　　者：金龙[1] 周文泉[2] 

机构地区：[1]山东省青岛市中医院 [2]中国中医研究院西苑医院,北京100091

出　　处：《中国中西医结合杂志》2004年第S1期18-20,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：中国中医研究院创新课题(No.05-11)

摘　　要：目的探讨络活胶囊对(L-NNA)造摸的高血压大鼠的疗效和作用机理。方法采用 L-NNA 诱导方法造模,将 SD 大鼠60只,随机分成6组,分别进行治疗。并观察治疗前后血压、心率及测定血浆 ET、AngⅡ、NO 含量。结果络活胶囊能降低高血压大鼠的血压、改善心率。并可显著降低高血压大鼠的血浆 ET、Ang Ⅱ水平,升高 NO 含量。结论络活胶囊对大鼠高血压有较好的疗效,其降压作用可能与降低 ET、AngⅡ水平,升高 NO 含量有关。Objective To explore the efficacy and its mechanism of Luohuo Capsule (LHC)on hypertension rats modeled by L -nitro-arginine (L-NNA).Methods L-NNA induced method was adopted in modeling.Sixty SD rats were randomly divided into 6 groups and given treatment respectively.Blood pressure(BP),heart rate (HR),serum level of endothelin (ET),angiotensin Ⅱ (Ang Ⅱ)and nitric oxide (NO) content before and after treatment were observed.Results LHC could lower BP of hypertensive rats,improve HR.Besides,it could significa...

关 键 词：络活胶囊 高血压 左旋硝基精氨酸 内皮素 血管紧张素Ⅱ 一氧化氮 

分 类 号：R285.5[医药卫生—中药学]