心复力冲剂对大鼠实验性心肌损伤的影响  

Protective Effect of Xinfuli Granule on Myocardial Cells in Rats with Myocardial Injury

作　　者：马丽红[1] 焦增绵[1] 范理礼[1] 阮英茆[1] 王亚芳[1] 司文学[1] 

机构地区：[1]中国医学科学院阜外心血管病医院中医科,北京100037

出　　处：《中国中西医结合杂志》2004年第S1期10-12,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家中医药管理局课题(No.972085)

摘　　要：目的观察心复力冲剂对大鼠实验性亚急性心肌细胞损伤、坏死的保护作用。方法 35只大鼠随机分为5组,每组6～8只。正常对照组与模型组喂饲生理盐水10ml/kg,各给药组分别灌胃心复力冲剂(5g/kg、10g/kg)和普萘洛尔(4mg/kg),每天1次,连续8天。除正常对照组外,各组于第5天给药后以异丙肾上腺素20mg/kg,皮下注射,连续4天,致大鼠心肌损伤、坏死。于实验第9天处死动物,取心脏,计算心脏系数。光镜下观察心肌细胞的坏死程度及炎性细胞浸润情况。结果经心复力冲剂防治后,大鼠心肌损伤程度明显减轻,病灶范围减少,以修复反应为主。结论心复力冲剂对实验性心肌损伤大鼠有明显的心肌保护和预防作用。To evaluate the protective effect of Xinfuli Granule(XFLG)on myocardial cells in rats with myocardial injury and necrosis.Methods Rat model of myocardial injury and necrosis was prepared by subcutaneously injecting isoproterenol (20 mg/kg).The rats were randomly divided into five groups.The normal group and the model group were treated by normal saline of 10 ml/kg,the large and small dosages XFLG group were medicated with XFLG 10 g/kg and 5 g/kg respectively,and the propranolol group was treated by proprano...

关 键 词：心肌损伤 心复力冲剂 病理形态 大鼠 

分 类 号：R285.5[医药卫生—中药学]