尿钠改变与窒息新生儿肾小管损伤的关系  

Relationship between the level of urinary Na^+ and post- asphyxial renal tubules infury in neonetes with asphyxia.

作　　者：朱正芳[1] 董文斌[1] 陈跃[2] 陈桃[1] 王胜会[1] 刘春艳[1] 

机构地区：[1]泸州医学院附属医院新生儿科,四川泸州646000 [2]泸州医学院附属医院核医学科,四川泸州646000

出　　处：《中国优生与遗传杂志》2004年第S1期94-95,共2页Chinese Journal of Birth Health & Heredity

基　　金：四川省卫生厅科研基金资助项目(编号 981017)

摘　　要：目的 探讨尿钠水平与窒息新生儿肾小管损伤的关系。方法 采用生化法和放射免疫分析法(RIA)分别检测窒息新生儿尿钠(Una)水平和反映肾小管损伤的指标-β2微球蛋白(β2-MG)。结果 重度窒息组(41.20±3.62mmol/L,4.66±1.85mgol/L)与正常组(22.03±2.58mmol/L,0.09±0.01mg/L)、轻度窒息组(29.40±2.60mmol/L,3.67±2.00mgol/L),以及轻度组与正常组相比较,Una和β2-MG水平显著升高(P<0.05或0.01),且Una和β2-MG水平之间呈显著正相关关系(r为0.72,P<0.05)。结论 尿钠水平的测定有望成为判断窒息程度及肾损伤的一个重要指标。Objective :To explore the relationship between the Na of urinary and post - asphyxial renal tubules injury in neonates with asphyxia. Methods: The level of Na+ (Una)and β2-micoglobulin(β2-MG)in urinary were detected in neonates with asphyxia. Resultes:Compared with the control(22.03±2.58mmol/L,0.09±0.01mg/L)and mild asphyxia group(29.40±2.60mmol/L,3.67±2.00mg/L),the level of Una and β2-MG(41.20±3.62mmol/L,4.66±1.85mg/L) were significantly increased in severe asphyxia group (P<0.05 or 0.01).The parameters...

关 键 词：窒息 新生儿 肾损伤 尿钠 Β2微球蛋白 

分 类 号：R722.17[医药卫生—儿科]