无症状HBsAg携带者及其子女转阴血淋巴细胞SCE及DNA损伤修复的研究  

Genetic study on the SCE and repairment of injured DNA of healthy carriers with HBsAg and their offspring.

作　　者：王瑜[1] 梁宇[1] 王振华[2] 

机构地区：[1]青岛大学医学院第二附属医院小儿科,青岛266042 [2]青岛大学医学院生物教研室,青岛266021

出　　处：《中国优生与遗传杂志》2004年第S1期32-33,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的 观察无症状HBsAg携带者及其子女姐妹染色单体交换(SCE)平均烦率的动态变化以及乙型肝炎病毒(HBV)感染引起的DNA损伤的自然修复。方法 本文采取前瞻性观察,采用20例无症状HBsAg携带者及其8例子女5年后自然转阴外周血淋巴细胞,同时将20例成人无症状HSsAg携带者及其8例携带者子女作为配对组,35例成人和10例儿童HBsAg阴性的健康者作为正常对照组,观察SCE交换频率的动态变化。结果 转阴组SCE均低于成人组和儿童组(P<0.05),而与正常组相比略有增高,但P>0.05。结论 HBV感染引起人类遗传物质损伤后,机体自身对于HBV-DNA修复产生遗传学效应。Objective:The dynamic change of healthy carriers with HBsAg and the following damages have caused much attention of medical staff at home and aboard because of the high positive rate of HBsAg (10-15%)and its natural increasing rate (0.7%)among the natural fiord of some national districts, while the dynamic change of the average frequency of sister chromatid exchange(SCE)of healthy carriers with HBsAg and their offspring as well as the natural repairment of in jured DNA as a result of HBV infection remained ...

关 键 词：无症状HBSAG携带者 姐妹染色单体交换(SCE) 

分 类 号：R512.62[医药卫生—内科学]