螺旋藻对实验性变应性鼻炎大鼠血清白细胞介素-4和干扰素-γ水平的影响  

Effect of Spirulina Platensis on Expression of Interleukin-4 and Interferon-γ in Serum of Experimental Allergic Rhinitis in Rat

作　　者：阳小云[1] 成丽兰[1] 徐军发[2] 章诗富[1] 

机构地区：[1]广东医学院附属医院,广东湛江524001 [2]广东医学院,广东湛江524023

出　　处：《实用医技杂志》2004年第8期1026-1027,共2页Journal of Practical Medical Techniques

基　　金：湛江市科委攻关项目 (2 0 0 1-85)

摘　　要：目的 :观察螺旋藻对实验性变应性鼻炎大鼠血清白细胞介素 - 4 (IL- γ)和干扰素 - γ(IFN- γ)的影响 ,以探讨其治疗机制。方法 :用卵清蛋白致敏大鼠制成变应性鼻炎动物模型 ,口服螺旋藻治疗 ,观察其行为学差异 ;用组织病理学方法观察鼻黏膜改变 ;用酶联免疫吸附法 (EL ISA)对血清中 IL - 4和 IFN-γ进行检测。结果 :行为学得分 ,阳性对照组 (7.8± 1.0 3)明显高于实验组 (1.6± 1.35 )和正常对照组 (0 ) ,差异有显著性 (P<0 .0 1) ;实验组鼻黏膜炎性反应明显轻于阳性对照组 ,实验组 IFN-γ水平明显高于阳性对照组 ,差异有显著性 (P<0 .0 1) ,实验组 IL - 4水平明显低于阳性对照组 ,差异有极显著性意义 (P<0 .0 1)。结论 :螺旋藻通过调节 IFN-γ和 IL - 4的表达 ,纠正失衡的 Th1 / Th2 的细胞因子网络而对变应性鼻炎产生治疗作用。Objective To observe level changes of serum Interleukin-4(IL-4) and interferon-γ(IFN-γ)in experimental allergic rhinitis(AR)of rats treated with Spirulina platensis and to study its therapeutic mechanism in AR.Methods White rats were sensitized by Ovalbumin as animal models of AR and they were treated orally with Spirulina platensis. During the treatment, the different behaviors were observed and the changes in the nasal mucosa were studied pathologically and the levels of serum IL-4、IFN-γweredetermined by...

关 键 词：螺旋藻 变应性鼻炎 白细胞介素-4 干扰素-Γ 

分 类 号：R96[医药卫生—药理学]