丹参注射液对不稳定型心绞痛患者血清sICAM-1的影响  

Effects of Salviae Miltiorrhize Compound Injectio on Serum in Patients with Unstable Angina Pectoris

作　　者：刘海陵[1] 扈友庄[1] 杨彬[1] 冯德辉[1] 

机构地区：[1]广东医学院附属医院,广东湛江524001

出　　处：《实用医技杂志》2004年第8期1021-1022,共2页Journal of Practical Medical Techniques

摘　　要：目的 :探讨不稳定型心绞痛 (UAP)患者血清中可溶性细胞间粘附分子 - 1(s ICAM- 1)和 C-反应蛋白(CRP)的水平与正常人的差异 ,及其在丹参注射液治疗前后的变化。方法 :随机将 6 4例 UAP患者分为常规治疗组及丹参注射液治疗组 (丹参组 ) ,观察治疗前后血清 s ICAM- 1和 CRP水平的变化 ,并与 2 2例正常对照组对比分析。结果 :UAP患者血清 s ICAM- 1和 CRP水平较正常对照组明显升高 (均为 P<0 .0 1) ,常规治疗组及丹参组治疗后s ICAM- 1及 CRP水平较治疗前明显降低 (均为 P<0 .0 1) ,且丹参组下降幅度较常规治疗组大 (P<0 .0 5 )。结论 :CRP、s ICAM- 1可能参与了冠心病 (CHD)的发病过程 ,血清 s ICAM- 1的检测有助于临床病情分析 ,丹参注射液能显著降低 UAP患者血清 s ICAM- 1和 CRP水平 ,从而降低冠脉事件的发生率。Objective To investigate the differences of serum soluble intercellular adhering molecular-1 (sICAM-1) and C-reactive protein (CRP) between the patients with unstable angina pectoris(UAP) contrasting with normal control and before and after the therapy with Salviae Miltiorrhize compound injectio.Methods 64 patients were divided randomly into conventional therapy and treatment with Salviae Miltiorrhize compound injectio. Serum sICAM-1 and CRP before and after therapy were measured and were compared with nor...

关 键 词：不稳定型心绞痛 丹参注射液 可溶性细胞间粘附分子-1 C-反应蛋白 

分 类 号：R259[医药卫生—中西医结合]