透明颤菌血红蛋白的生理功能机制与应用  

The physiological function mechanism and application of Vitreoscilla Hemoglobin

作　　者：周艳芬[1] 赵晓瑜[1] 静天玉[1] 李亚东[1] 乔环宇[1] 

机构地区：[1]河北大学生命科学学院,河北保定071002

出　　处：《河北农业大学学报》2003年第z1期139-141,共3页Journal of Hebei Agricultural University

摘　　要：透明颤菌在贫氧条件下能大量合成一种同源双亚基血红蛋白。在异源宿主中表达该蛋白常常可以促进微生物生长 ,提高降解有毒代谢物的能力 ,促进氧的存贮和氧的传递 ,增加氧的流量。最新研究显示 ,透明颤菌血红蛋白将氧直接传送给完整的细胞色素bo末端氧化酶亚基Ⅰ ,并在亚基Ⅰ的双核心处将氧还原成水 。The bacterium, Vitreoscilla, can induce the sythesis of a homodimeric hemoglobin(VHb) under hypoxic environmental conditions. Expression of VHb in heterologous hosts often enhances microbial growth, increases degradation of toxic wastes, and facilitates oxygen storage and transfer by generating sufficient oxygen flux. Recently, there is evidence that VHb can function only when VHb interacts with intact subunitⅠof cychrome bo which contains the binuclear center where the oxygen that could be directly delivered by VHb is reduced to water. So the interaction between VHb and cychrome bo is of physiological importance.

关 键 词：透明颤菌血红蛋白(VHb) 细胞色素bo末端氧化酶 结构 功能 

分 类 号：Q26[生物学—细胞生物学]