A New Method of Deoxygenation in the Synthesis of Taxanes by Hypophosphorous Acid  

作　　者：GU Jun ZHANG Meng YIN Da-Li 

机构地区：[1]Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050 Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050 Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050

出　　处：《有机化学》2003年第z1期340-341,共2页Chinese Journal of Organic Chemistry

基　　金：Project supported by the National Natural Science Foundation of China (No. 30100230).

摘　　要：　　Based on the chemistry involved in the radical chain deoxygenation of alcohols by the Barton-McCombie reaction, numerous applications in the synthesis of taxanes were reported. [1] In the original Barton-McCombie method,tributyltin hydride was the hydrogen atom source and tributyltin radical generated from the hydride served as a chain carrier. [2] Although the method gave the good yield and found many applications, the problems associated with the price, toxicity and removal of tin residues prompted search for other hydrogen atom sources. Radical chain deoxygenation of alcohols can be carried out with phosphorus centered radicals, generated from hypophosphorous acid orits salts. [3]……

分 类 号：O62[理学—有机化学]