Solvent-free Synthesis of 5-Azacytosine with Microwave Activation  

作　　者：QU Gui-Rong LIU Qi-Bin ZHANG Wen-Sheng Feng Feng 

机构地区：[1]Key Laboratory of Environmental Science and Technology of High Education of Henan Province, College of Chemical & Environmental Science, Henan Normal University, Xinxiang 4530022 [2]Department of Chemistry, Jiaozuo Normal College, Jiaozuo 454151

出　　处：《有机化学》2003年第z1期106-106,共1页Chinese Journal of Organic Chemistry

基　　金：Project supported by the National Natural Science Foundation of China (No. 29972010).

摘　　要：5-Azacytosine (4-amino-1,2-dihydro-1,3,5-triazin-2-one) is a very important intermediate in the synthesis of 5-azacytidine which shows remarkable bacteriostatic and cytostatic activity as well as against T-4 lymphoma and L1210 leukemia in mice. Starting with N-cyanoguanidine (dicyandiamide) and formic acid, under the solvent-free microwave activation, we synthesized 5-azacytosine in short time (4 min) with good yield (60.4%). The structure of the product was confirmed by 1H NMR and elemental analysis.……

分 类 号：O62[理学—有机化学]