Microwave-Assisted Soluble Polymer-supported Synthesis of Peptoids  

作　　者：XU Guo-Yu ZHANG Gang-Shen YANG Gui-Chun CHEN Zu-Xing 

机构地区：[1]Faculty of Chemistry and Material Science, Hubei University, Wuhan 4.30062 Faculty of Chemistry and Material Science, Hubei University, Wuhan 4.30062 Faculty of Chemistry and Material Science, Hubei University, Wuhan 4.30062 Faculty of Chemistry and Material Science, Hubei University, Wuhan 4.30062

出　　处：《有机化学》2003年第z1期115-115,共1页Chinese Journal of Organic Chemistry

摘　　要：　　Libraries of peptide-like compounds are attractive sources of binding agents for proteomics applications. The synthesis of oligomeric combinatorial libraries of peptidomimetics is usually more straightforward than the creation of large libraries of more "drug-like" molecules. Herein we report synthesis of peptoids on soluble high loading Noncross-linked polystyrene. The synthesis route consists of: (a) preparation "soluble wang resin" from non-crosslinked polystyrene and 4-hydroxybenzyl alcohol via ether linkage, (b) an esterification step performed by the addition of bromoacetyl bromide to "soluble wang resin" and (c) a nucleophilic displacement of bromide with a primary amine.……

分 类 号：O62[理学—有机化学]