植入型丹参缓释剂治疗股骨头坏死的实验研究  

Experimental study of the treatment of the necrosis of the femoral head with implantation of controlled-re-leasing salvia miltiorrhizae

作　　者：曹斌[1] 刘永辉[1] 王开友[1] 张守平[1] 赵新刚[1] 俞能宝[1] 

机构地区：[1]青岛海慈医院骨科,山东青岛266033

出　　处：《中国骨伤》2003年第9期516-518,共3页China Journal of Orthopaedics and Traumatology

基　　金：山东省科委立项课题(00313126)

摘　　要：目的 研究丹参缓释剂植入股骨头内治疗股骨头坏死的效果。方法 参照Rich等方法,用马血清、醋酸强的松龙复制家兔股骨头坏死的动物模型,造模8周后实验组(A组)将丹参缓释剂40mg植入到右侧股骨头内。对照组(B组)用同样方法植入赋形剂40 mg。正常对照(C组)。术后不同时间做X线摄片、ECT扫描、组织学及扫描电镜检查。结果 X线片示A组右侧股骨头骨密度增高,透光区较小,B组骨密度减低,有大小不等透光区;ECT扫描示A组静态放射性分布中等浓聚,而B组静态图像放射性分布呈炸面包圈样改变,欠均匀;组织学检查显示A组骨空陷窝率、血管数、骨髓腔内脂肪细胞直径较B组明显改善(P<0.01);扫描电镜检查显示A组松质骨结构较规则,骨陷窝结构完整,部分骨板断裂,骨小管可见。B组结构紊乱不清,骨板断裂,骨陷窝少,骨小管消失。结论 丹参缓释剂植入到坏死的股骨头模型内,能改善股骨头血供,促进坏死骨的吸收、修复与重建。为股骨头坏死这种新的治疗方法提供实验依据。Objective To study the treatment of the necrosis of the femoral head with implantation of controlled-releasing salvia miltiorrhizae Methods According to Rich's method, the animal model of the necrosis of the femoral head was made. The animals were divided into three groups, the experimental group with implantation of controlled-releasing salvia miltiorrhizae at 8 weeks, the sham control group with 40 mg excipient and the control group. X-ray, ECT scanning, histological examination and SEM were done at different times after the operation. Results X-ray showed that bone density of the right side increases and the transparent area is relatively small in the experimental group. While in the sham control group, density reduced and transparent areas with different size were unevenly distributed. ECT scanning showed static radiation distribution of the experimental group moderately concentrating, while the sham control group changed unevenly in all directions, Histological examination showed that the lacuna rate, blood vessels and diameter of the fatty cell in marrow cavity has remarkably improved compared to the sham control group (P< 0.01). SEM examination showed that the experimental group has regular spongiest structure,complete bone lacuna structure,partial broken os-teone and visible bone canaliculus, while the sham control group has disorderly structure, broken osrteone, little bone lacuna and total invisibility of bone canaliculus. Conclusion The implantation of controlled release salvia into the necrosis of the femoral head in animal models can improve blood supply of the femoral head, promote absorption of the necrosis bone,repair the femoral head. The experiment provides a basis for treatment of the necrosis of the femoral head.

关 键 词：股骨头坏死 组织学 丹参 

分 类 号：R68[医药卫生—骨科学]