糙叶败酱中木脂素成分研究  

Studies on the lignans from Patrinia scabra

作　　者：李廷钊[1] 张卫东[1] 顾正兵[1] 刘文庸[1] 周静[2] 陈万生[1] 

机构地区：[1]第二军医大学药学院,上海200433 [2]上海长征医院药剂科,上海200003

出　　处：《药学学报》2003年第7期520-522,共3页Acta Pharmaceutica Sinica

摘　　要：目的　研究糙叶败酱 (PatriniascabraBge .)中的木脂素类化学成分。方法　应用柱色谱和HPLC法分离纯化 ,通过光谱 (IR ,MS ,1 HNMR ,1 3CNMR ,DEPT ,HMQC和HMBC)鉴定其化学结构。结果和结论　分离并鉴定了 4个木脂素类化合物 ,分别鉴定为 :落叶松脂醇 (1) ,4 [1 乙氧基 1 (4′ 羟基 3′ 甲氧基 )苯基 ]甲基 2 (4 羟基 3 甲氧基 )苯基 3 羟甲基四氢呋喃 (2 ) ,异落叶松树脂酚 (3) ,去甲络石糖苷 (4)。化合物 2为新的木脂素 ,化合物 3,4为首次从该属植物中分得。Aim To study the lignans from Patrinia scabra Bunge. Methods The constituents were separated and purified by column chromatography with silical gel, RP-silical gel and Sephadex LH-20. Their structures were identified on the basis of spectral data (IR, MS, 1HNMR, 13 CNMR, HMQC and HMBC). Results and Conclusion A new lignan was obtained and its structure was elucidated as 4-[1-ethoxyl-1-(4-hydroxy-3-methoxy)benzyl]methyl-2-(4-hydroxy-3-methoxy)benzyl-3-hydroxymethyl-tetrahydro-furan (2), along ...

关 键 词：糙叶败酱 木脂素 4-[1-乙氧基-1-(4′-羟基-3′-甲氧基)苯基]甲基-2-(4-羟基-3-甲氧基)苯基-3-羟甲基四氢呋喃 

分 类 号：R284[医药卫生—中药学]