地塞米松、吲哚美辛和白藜芦醇对巴豆油致炎小鼠耳部基质金属蛋白酶-9的抑制作用  

Inhibition of dexamethasone,indomethacin and resveratrol on matrix metalloproteinase-9 and the mechanism of inhibition

作　　者：李怡棠[1] 沈放[1] 白金叶[1] 程桂芳[1] 

机构地区：[1]中国医学科学院,中国协和医科大学药物研究所,北京100050

出　　处：《药学学报》2003年第7期501-504,共4页Acta Pharmaceutica Sinica

摘　　要：目的　研究巴豆油致炎小鼠耳部基质金属蛋白酶 9(MMP 9)的表达 ,以及地塞米松、吲哚美辛和白藜芦醇对MMP 9表达的影响。方法　免疫组织化学法测定巴豆油致炎小鼠耳部MMP 9表达 ,明胶酶谱法测定U937细胞MMP 9表达。结果　地塞米松和吲哚美辛以及白藜芦醇对巴豆油引起的小鼠耳肿胀有明显抑制作用 ;对巴豆油引起的小鼠耳部MMP 9表达以及PMA诱导的U937细胞MMP 9表达也有显著抑制作用。结论　巴豆油致炎小鼠耳部MMP 9表达增高 ;地塞米松、吲哚美辛和白藜芦醇的抗炎作用可能与抑制MMP 9表达增高有关。Aim To investigate the expression of matrix metalloproteinase-9 (MMP-9) in mouse ears induced with croton oil and the inhibitory effect of dexamethasone, indomethacin and resveratrol on MMP-9 expression, and further explore the relationship between anti-inflammation and MMP-9 inhibition of these three medicines. Methods Immuno-histochemistry was used to detect the expression of MMP-9 in mouse ears. Expression of MMP-9 in U937 cells was analyzed by gelatin zymography. Results Mouse ear edema induced with ...

关 键 词：基质金属蛋白酶-9 地塞米松 吲哚美辛 白藜芦醇 

分 类 号：R965[医药卫生—药理学]