液相中制备尼群地平的固体分散体缓释微球  

Preparation of sustained-release nitrendipine microspheres with a solid dispersed structure in liquid system

作　　者：杨明世[1] 崔福德[1] 杨鹤[1] 高鹏[1] 岳鹏[1] 王亮[1] 范玉玲[1] 

机构地区：[1]沈阳药科大学药学院药剂教研室,辽宁沈阳110016

出　　处：《药学学报》2003年第8期634-638,共5页Acta Pharmaceutica Sinica

基　　金："九.五"国家重点科技攻关项目(96-90 2 -0 2 -15 )

摘　　要：目的　在液相中制备尼群地平的固体分散体缓释微球并研究其影响因素。方法　采用球晶造粒技术与溶剂沉积法相结合的方法 ,以滑石粉为固体分散体载体 ,EudragitRSPO为阻滞剂 ,在液相中一步制备尼群地平的固体分散体微球 .考察了微球的收率、粉体性质及影响微球成形和释放速度的因素。结果　采用该方法制备的尼群地平缓释微球圆整、均匀 ,粒径在 2 80～ 90 0 μm的微球收率可达 70 %以上 ,堆密度在 0 7kg·L- 1 左右 ,药物的包封率可达95 %以上 ,微球的成形主要受溶剂系统中液体架桥剂量和不良溶剂中乳化剂的影响 ,药物从微球中的释放速度可通过调节处方中阻滞剂和分散剂的量的比例控制。Aim To prepare the sustained release nitrendipine microspheres with a solid dispersed structure in liquid system. Methods The sustained release nitrendipine microspheres with a solid dispersed structure was prepared in liquid system by combining spherical crystallization technique and solvent deposition method in one step. The resultant microspheres were evaluated for the recovery, micromeritc properties, incorporation efficiency. The factors of effect on the formation and the release rate of microspher...

关 键 词：球晶造粒技术 溶剂沉积法 尼群地平 缓释微球 

分 类 号：R943[医药卫生—药剂学]