双氯芬酸钠脉冲控释微丸的研究  

Studies on diclofenac sodium pulsatile release pellets

作　　者：郭涛[1] 郑春丽[1] 宋洪涛[1] 隋因[1] 党大胜[1] 孙学惠[1] 

机构地区：[1]沈阳军区总医院药剂科,辽宁沈阳110016

出　　处：《药学学报》2003年第9期707-710,共4页Acta Pharmaceutica Sinica

基　　金：全军医药卫生科研基金"十五"重点规划课题资助项目 (0 1Z0 0 4)

摘　　要：目的　制备双氯芬酸钠脉冲控释微丸 (DS PRP)并考察体内外释药特性。方法　采用水溶胀性材料为内包衣溶胀层 ,乙基纤维素水分散体为外包衣控释层制备DS PRP ,考察影响其体外释药的因素 ,并进行体内药代动力学研究。结果　溶胀层材料类型、溶胀层和控释层包衣厚度、释放介质中十二烷基硫酸钠 (SDS)的加入对DS PRP的释药时滞和释药速率有显著影响 ,在 0 1%SDS溶液中释药时滞T0 1 为 3 1h ,体内释药时滞Tlag为 2 8h ,与DS丸芯的相对生物利用度为 ( 91± 12 ) %。结论　DS PRP在体内外均具有脉冲释药特性。Aim To investigate the preparation of diclofenac sodium pulsatile release pellets (DS PRP), the release in vitro and the pharmacokinetics of the drug. Methods Diclofenac sodium (DS) core pellets prepared by extrusion spheronization technology were coated in a mini fluidized bed spray coater with swelling material as the inner coating swelling layer and ethylcellulose aqueous dispersion as the outer coating controlled layer. The effects of formulation and medium on pulsatile release of DS were inves...

关 键 词：双氯芬酸钠 脉冲控释微丸 药代动力学 生物利用度 

分 类 号：R944[医药卫生—药剂学]