结合亚油酸对胰岛素抵抗模型MSG肥胖小鼠的影响  

Effects of conjugated linoleic acid on obese MSG mice with insulin resistance

作　　者：孙素娟[1] 申竹芳[1] 陈跃腾[1] 唐玲[1] 丁世英[1] 谢明智[1] 

机构地区：[1]中国医学科学院,中国协和医科大学药物研究所,北京100050

出　　处：《药学学报》2003年第12期904-907,共4页Acta Pharmaceutica Sinica

摘　　要：目的　研究结合亚油酸对胰岛素抵抗模型MSG肥胖小鼠的胰岛素抵抗是否有改善作用。方法　建立胰岛素抵抗模型后分为模型、结合亚油酸和罗格列酮组 ,观察结合亚油酸对MSG小鼠肥胖、葡萄糖代谢、胰岛素抗性、血及脂肪组织中TNF α含量等的影响。结果　结合亚油酸使MSG小鼠体重增长减少 ,体型明显改变 ,但对MSG小鼠异常的胰岛素和葡萄糖耐量、高胰岛素血症及脂肪组织中TNF α含量升高均无改善 ,使胰岛素敏感指数明显降低。结论　结合亚油酸对MSG小鼠有一定减肥作用 ,对MSG小鼠的胰岛素抵抗无改善作用。Aim To study the effect of conjugated linoleic acid (CLA) on obese MSG mice with insulin resistance. Methods About four months old, obese MSG mice with insulin resistance were divided into control, CLA and rosiglitazone groups and drugs were administrated ig once a day. Body weights were recorded regularly, insulin and glucose tolerance were tested. In addition, serum insulin and TNF-α concentrations in serum and fat tissues were determined. Results CLA was shown to reduce the body weight and fat weight ...

关 键 词：结合亚油酸 MSG小鼠 胰岛素抵抗 2型糖尿病 

分 类 号：R965[医药卫生—药理学]