单层芯渗透泵片用于水不溶性药物的控制释放  

Unitary-core osmotic pump tablet for controlled release of water-insoluble drug

作　　者：刘龙孝[1] 徐清[2] 姜吉善[3] 李钟文[3] 李海邦 

机构地区：[1]浙江大学药学院,浙江杭州310027 [2]浙江大学校医院,浙江杭州310027 [3]全北大学高分子工学科 [4]韩国化学研究院生物材料研究室

出　　处：《药学学报》2003年第12期966-967,共2页Acta Pharmaceutica Sinica

基　　金：教育部留学回国人员科研启动基金资助项目 (教外司留 [2 0 0 0 ] 479号 )

摘　　要：Aim To study unitary-core osmotic pump tablet for delivering water-insoluble drug for 24 hours. Methods Unitary-core osmotic pump tablet was prepared using nifedipine as the model drug. The effects of various core formulation variables on drug release were studied. Results Polyethylene oxide and potassium chloride have comparable positive effects on drug release, whereas, nifedipine has markedly negative effect on drug release. Conclusion Unitary-core osmotic pump tablet is very easy in preparation and it can deliver water-insoluble drug in substantially constant rate for 24 hours.Aim To study unitary-core osmotic pump tablet for delivering water-insoluble drug for 24 hours. Methods Unitary-core osmotic pump tablet was prepared using nifedipine as the model drug. The effects of various core formulation variables on drug release were studied. Results Polyethylene oxide and potassium chloride have comparable positive effects on drug release, whereas, nifedipine has markedly negative effect on drug release. Conclusion Unitary-core osmotic pump tablet is very easy in preparation and ...

关 键 词：单层芯渗透泵片 水不溶性药物 硝苯吡啶 控制释放 

分 类 号：R94[医药卫生—药剂学]