反式曲马朵在大鼠小肠中吸收的立体选择性  

Stereoselectivity in absorption of trans tramadol in rat intestine

作　　者：刘会臣[1] 李保欣[1] 顿彬[1] 王永利[2] 

机构地区：[1]白求恩国际和平医院临床药理室,河北石家庄050082 [2]河北医科大学药理教研室,河北石家庄050017

出　　处：《药学学报》2003年第12期893-896,共4页Acta Pharmaceutica Sinica

摘　　要：目的　研究反式曲马朵 (transT)在大鼠小肠中吸收的立体选择性。方法　高效毛细管电泳法测定小肠分段灌流液中transT对映体的浓度。结果　TransT对映体在小肠不同部位的吸收分数基本一致 ;在低浓度时 (+) transT的吸收分数明显低于 (- ) transT ;在高浓度时transT对映体的吸收分数降低 ,(+) transT与 (- ) transT的吸收分数无明显差别。结论　TransT在大鼠小肠的不同部位均能被吸收 ,具立体选择性 ,以 (- ) transT占优。Aim To investigate the stereoselectivity in absorption of trans tramadol ( trans T) in rat intestine. Methods The duodenum, jejunum and ileum were separately perfusated in situ with trans T dissolved in Krebs-Ringer buffer. Trans T enantiomers in the perfusate were analyzed with a high performance capillary electrophoresis (HPCE) method. Results The absorbed fractions of trans T enantiomers were similar among the different segments of the rat intestine. The absorbed fraction of (+)- trans T was lower tha...

关 键 词：反式曲马朵 对映体 小肠中吸收 立体选择性 

分 类 号：R965[医药卫生—药理学]