NK细胞和NKT细胞在病毒性肝炎中的作用  

Role of NK cell and NKT cell in viral hepatitis

作　　者：王敏[1] 王福生[1] 

机构地区：[1]解放军302医院生物工程室,北京100039

出　　处：《免疫学杂志》2003年第S1期138-141,共4页Immunological Journal

摘　　要：NK细胞(Natural killer cells)和NKT细胞(Natural killer T cells)参与机体的天然免疫反应。NK细胞在肝炎病毒感染的早期免疫反应中起到重要作用,而慢性病毒性肝炎患者NK细胞功能降低。另外,动物实验显示NKT细胞可致肝组织损伤并能抑制肝炎病毒的复制。因此通过调节NK细胞和NKT细胞的功能治疗病毒性肝炎将有可能成为一种新的策略。Natural killer (NK) cells and natural killer T( NKT) cells participate in human innate immune response. NK cells are important in the early response of immune system to the hepatitis virus infection. Patients with chronic hepatitis show decreased NK activity. In addition, animal experiments show that NKT cells could induce hepatocyte injury and inhibit hepatitis virus replication. So therapy for viral hepatitis by regulating NK and NKT activity maybe a new strategy.

关 键 词：NK细胞 NKT细胞 病毒性肝炎 

分 类 号：R512.6[医药卫生—内科学]