补肾益气中药对溴隐亭致流产大鼠蜕膜Th1/Th2型细胞因子的影响  

Effect of Bushen Yiqi Herbs on Th1/Th2 Type Cytokine on Decidua in Bromocriptine Induced Abortion Rats

作　　者：蒋立辉[1] 归绥琪[1] 储以薇[2] 李昆明[1] 

机构地区：[1]复旦大学妇产科医院 [2]复旦大学医学院免疫学教研室

出　　处：《中国中西医结合杂志》2003年第S1期186-189,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：上海市科学技术发展基金(No.98-203)

摘　　要：目的:探讨补肾益气中药对流产大鼠的保胎机理。方法:采用孕6、7、8天皮下注射溴隐亭0.125mg/d 诱发 SD 大鼠流产模型,以半定量逆转录多聚酶链式反应(RT-PCR)方法测蜕膜 Th1/Th2型细胞因子的表达,观察中药治疗对以上指标的影响。结果:补肾益气中药可使溴隐亭致流产大鼠蜕膜 Th1/Th2型细胞因子平衡恢复正常。结论:中药可通过对母胎界面 Th1/Th2型细胞因子平衡的调控维持妊娠。Objective:To study the immunologic mechanism of Bushen Yiqi (BSYQ) herbs in protecting bromocriptine induced abortion in rats.Methods:Sixty-one SD rats were randomly divided into 5 groups:Group A:treated with BSYQ herbs for 12 days from the day of vaginal plug observed,and injected with bromocriptine 0.125mg/d subcutaneously (sc) during day 6-8 of pregnancy;group B:in- jected with bromocriptine during the day 6—8 of pregnancy;group C:rats injected with bromocriptin 31ul/d sc at day 6-8 of preg- nancy;group ...

关 键 词：中药 溴隐亭 流产模型 TH1/TH2细胞因子 

分 类 号：R285.5[医药卫生—中药学]