胆必清颗粒治疗大鼠急性细菌性腹膜炎的实验研究  

Experimental Study of Danbiqing Granule in Treating Rats with Acute Bacterial Peritonitis

作　　者：公衍玲 王宏波[2] 孟林[3] 林秀珍[3] 

机构地区：[1]山东省海洋药物科学研究所,山东青岛266003 [2]山东省即墨市人民医院普外科 [3]天津医科大学药理教研室

出　　处：《中国中西医结合杂志》2003年第S1期203-205,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：天津市"九五"攻关课题(No.983113411)

摘　　要：目的:研究胆必清颗粒对实验性急性细菌性腹膜炎大鼠的保护作用,初步探讨其抗炎作用机理。方法:以大鼠为研究对象,建立急性细菌性腹膜炎模型,随机分为6组,胆必清高、中、低剂量组、氨苄青霉素组、模型组及对照组,分别检测血清肿瘤坏死因子-α(TNF-α),白细胞介素-6(IL-6),磷脂酶 A_2(PLA_2)和肝组织 PLA_2水平。结果:与对照组比较,模型组血清 TNF-α,IL-6,PLA_2和肝组织 PLA_2水平均明显升高(P<0.01)。各胆必清治疗组的上述指标均有所下降(P<0.05或 P<0.01).结论:胆必清颗粒能明显抑制炎性因子 PLA_2和炎性细胞因子 TNF-α、IL-6的产生,具有抗炎作用。Objective:To study the effect of Danbiqing Granule (DG) on experimental rats with acute bacterial peritonitis and primarily ex- plore its mechanism of anti-inflammation.Methods:Rat model of acute bacterial peritonitis was set up.Tumor necrosis factor-α(TNF- α),interleukin-6 (IL-6),level of phospholipase A_2(PLA_2) in serum and PLA_2 in liver tissue were determined respectively in 6 groups,they were DG groups of large,middle,small dosage;ampicillin group,model group and control group,Results:Compared with th...

关 键 词：肿瘤坏死因子-Α 白细胞介素-6 磷脂酶 A_2 腹膜炎 胆必清颗粒 

分 类 号：R285.5[医药卫生—中药学]