8种中药煎剂对银屑病角质形成细胞C-erbB-1表达的抑制作用  

Inhibitory Effect of 8 Chinese Herbal Decoctions on Expression of C-erbB-1 in Psoriatic Keratinocytes

作　　者：周利平[1] 高进[1] 胡长发[1] 王玮臻[1] 

机构地区：[1]武汉市第一医院皮肤科,武汉430022

出　　处：《中国中西医结合杂志》2003年第S1期195-197,共3页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的:观察8种中草药(雷公藤、白花蛇舌草、黄柏、黄芩、茯苓、红花、板蓝根、丹参)煎剂对银屑病角质形成细胞内 C-erbB-1癌基因表达的抑制作用,探讨中草药治疗银屑病可能的作用机理。方法:8种中草药分别与体外培养的银屑病角质形成细胞和经银屑病患者外周血白细胞刺激的正常人角质形成细胞共同培养,采用细胞原位杂交的方法检测细胞中 C-erbB-1mRNA 的表达。结果:8种中草药对银屑病患者角质形成细胞内 C-erbB-1的表达有不同程度的抑制作用(P<0.001),抑制作用最强的为雷公藤;中药对经银屑病患者外周血白细胞刺激的正常人角质形成细胞内 C-erbB-1的表达也有不同程度的抑制作用(P<0.001),抑制作用最强的为茯苓。结论:这些中药可能通过抑制银屑病角质形成细胞 C-erbB-1的表达来抑制表皮细胞的增殖。Objective:To study the effect and mechanism of 8 kinds of Chinese herbal decoctions in treating psoriasis with observation of in- hibitory effect on expression of C-erbB-1 in psoriatic keratinocytes.Methods:8 Chinese herbal decoctions (Tripterygium wilfordii, Oldenlandia diffusa,Phellodendron chinense,Astragalus membranaceus,Poria cocos,Carthamus tinctorius,Isatidis indigotica,Salvia miltiorrhizae) were observed,which were separately cultured with psoriatic keratinocytes and normal keratinocytes stimulated ...

关 键 词：银屑病 原癌基因 C-erbB-1 原位杂交 

分 类 号：R275[医药卫生—中医皮科]