当归芍药散加味方及拆方对大鼠松果体β-肾上腺受体含量和功能的影响  

Effect of Supplemented Danggui Shaoyao San and Its Dissembled Prescription on β-Adrenergic Receptors and Functions of Pineal Body in Aged Rats

作　　者：何宏文[1] 王传恩[1] 卢汉平[1] 谢瑶[1] 姚志彬[1] 

机构地区：[1]广州中山大学中山医学院人体解剖学教研室脑研究室,广州510089

出　　处：《中国中西医结合杂志》2003年第S1期69-72,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金(No.30070952)

摘　　要：目的:研究当归芍药散加味方对老年鼠松果体β肾上腺受体(β-AR)含量及功能的影响。方法:选用老年鼠(18个月),分组灌服当归芍药散加味方及其君臣药、佐药水煎液,3周后,用放射配基受体结合分析法测定其松果体β-AR,同时用四唑蓝比色法(MTT)测定各组大鼠松果体培养上清液(PCS)促进脾细胞ConA 诱导 T 淋巴细胞增殖 OD 值(SCTOD 值)。结果:与老年对照组比较,当归芍药散全方组大鼠松果体β-AR 明显增多(P<0.01),当归芍药散全方组和君臣药组大鼠 PCS 对 SCTOD 值明显增多(P<0.01)。结论:结果表明当归芍药散加味方可提高老年鼠松果体β-AR,使松果体可分泌较多的促进淋巴细胞增殖的物质。Objective:To study the effect of supplemented Danggui Shaoyao San (DSS) and its dissembled prescription on β-adrenergic re- ceptor (β-AR) level and function of pineal body in aged rats.Methods:Aged rats (18 months) were divided groups according to the principal-adjuvant and auxilliary medicine of DSS fed to the rats through gastrogavage for 21 days.Then,using radioligand binding assay of receptor,β-AR level of pineal body was determined.Using MTT method,after pineal culture supernatant(PCS) was added to cul...

关 键 词：当归芍药散 β肾上腺受体 衰老 松果体 

分 类 号：R285.5[医药卫生—中药学]