黄芪和镁剂治疗创伤性窒息脑损害的实验研究  

Experimental Study of Astragalus Membranaceus and Magnesium in Treating Traumatic Asphyxia-Induced Delayed Neuronal Damage Injury

作　　者：邱永明[1] 田鑫[1] 陈付学[2] 罗其中[1] 陆兆丰[1] 

机构地区：[1]上海第二医科大学附属仁济医院神经外科,上海200001 [2]上海大学生命学院

出　　处：《中国中西医结合杂志》2003年第S1期67-69,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金(No.39900153);上海市科委资助(No.984019031)

摘　　要：目的:探讨黄芪和镁剂治疗创伤性窒息脑迟发性神经元损伤的效果及机制。方法:应用大鼠行为学研究(十字离地迷宫试验)和病理形态学(海马 CA1区神经元计数及 TUNEL 染色观察 DNA 断裂)研究治疗前后大鼠的神经功能改变。结果:黄芪可减轻创伤性窒息大鼠海马迟发性神经元损伤,减轻大鼠的焦虑状况、加强其活动性;镁剂亦有与黄芪类似的改善受损神经元的作用,其作用效果稍差于黄芪。黄芪和镁剂的联合应用未见明显毒副作用。结论:黄芪、镁剂的早期使用对创伤性窒息脑损害具有保护作用,其实际应用前景广阔。Objective:To investigate the mechanism and effects of Astragalus membranaceus (AM) and/or magnesium on traumatic as- phyxia-induced delayed cerebral injury in rats.Methods:Rat model of traumatic asphyxia was established with 4 groups of control and treatment.By use of behavioral study (elevated X-maze test) and pathological study (hippocampal CA_1 neuron count and DNA split with TUNEL stain) on neural functions of model rats were studied with or without administration of the treating agents.Results: AM coul...

关 键 词：创伤性窒息 脑损害 黄芪 镁 

分 类 号：R641[医药卫生—外科学]