脑伤泰对血管性痴呆大鼠认知障碍及海马钙结合蛋白的影响  

Effect of Naoshangtai in Treating Learning-Memory Dysfunction and Calbindin of Hippocampus in Vascular Dementia Rats

作　　者：周建军 冯华[2] 王宪荣[2] 吴国材[2] 

机构地区：[1]西安第323医院骨科,西安710054 [2]第三军医大学西南医院神经外科,重庆400038

出　　处：《中国中西医结合杂志》2003年第S1期47-50,共4页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的:观察中药脑伤泰对血管性痴呆大鼠主动回避反应及海马钙结合蛋白的影响。方法:采用Pulsinelli 氏血管闭塞法建立血管性痴呆模型。脑伤泰治疗,通过主动回避反应正确率观察痴呆大鼠治疗前后学习记忆功能的变化,免疫组化法检测海马钙结合蛋白表达变化。结果:治疗组经过6周、8周治疗后,其主动回避反应正确率有明显改善,海马钙结合蛋白表达较模型组明显提高。结论:脑伤泰对血管性痴呆大鼠学习记忆功能有一定的改善作用,可能与提高海马钙结合蛋白表达有关。Objective:To investigate the effects of Naoshangtai (NST) in treating learning and memory function and calbindin (CAB) of hippocampus in rats with vascular dementia (VD).Methods:Pulsinelli s vascular occlusion method was adopted to establish a model of vascular dementia in Wistar rats which were subsequently treated with NST.Learning and memory functions were evaluated by the active avoidance response (AAR).The hippocampus were then stained with immunohistochemistry to detect the expession of CaB. Results:S...

关 键 词：血管性痴呆 大鼠 学习记忆 钙结合蛋白 主动回避反应 脑伤泰 

分 类 号：R285.5[医药卫生—中药学]